ONE GENETIC MEDICINE.
THOUSANDS OF DISEASES.

Arginine to TGA (Arg-TGA) liver stop codon disease can affect patients with Arg-TGA mutations in any genetic disease of the liver, including phenylketonuria, organic acidemias, and urea cycle disorders. The Arg-TGA mutation is the most prevalent nonsense mutation in the liver.

Glutamine to TAG (Gln-TAG) liver stop codon disease can affect patients with Gln-TAG mutations in any genetic disease of the liver, including phenylketonuria, organic acidemias, and urea cycle disorders.

Alltrna’s engineered tRNA are designed to precisely replace the correct amino acid that would be present without a nonsense mutation. Future programs are intended to bring forward tRNA medicines to address other stop codon liver disease patients based on their nonsense mutation type.